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InChi: InChI=1S/C24H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h7-8
Smiles: [O-][N+](=O)C1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C43)C2=C1
but not in the YM cell line
Large-scale CTX- 0294885 -based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells
2014 Nov 10
MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 InChi: InChI=1S/C24H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h7-8MAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED