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and dose-dependent neuronal death
Smiles: CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3F)=C(C=C12)C(=O)NOCCO
High affinity proteasome inhibitor (Ki = 0
Formula: C15H24N2O
Tylan 10 premix
CZC-54252 443 and dose-dependent neuronal deathCZC 54252 is a potent inhibitor of leucine rich repeat kinase 2 (LRRK2) with IC50 values 1. 28 nM and 1. 85 nM for wild type and G2019S mutant forms of LRRK2 respectively. CZC 54252 attenuates neuronal injury induced by LRRK2 G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic
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