IMR-1 - CAS# 310456-65-6 Size:10mg solid potent and selective XPO1/CRM1 Inhibitor

potent and selective XPO1/CRM1 Inhibitor

Smiles: CCOC(=O)C1=CN=C2C=CC(=CN21)C1=CN=CC(=C1)NS(=O)(=O)C1C=CC=CC=1

6-diamino-3-{[(2R

For the convenience of communication

68(12):1077-81

IMR-1 - CAS# 310456-65-6 Size:10mg solid potent and selective XPO1/CRM1 InhibitorIMR 1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26 M. IMR 1 prevents the recruitment of Mastermind like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth. Product information CAS Number: 310456 65 6 Molecular Weight: 353. 41 Formula: C15H15NO5S2 Chemical Name: ethyl 2 (2 methoxy 4 {[(5E) 4 oxo 2 sulfanylidene 1,