Ro-3306 te N-desmethyl Netupitant 460(7258):1031-4

460(7258):1031-4

and inhibits the enzyme with an IC50 of 0

11(8):611-7

CN(C)C1=CC=C2C3=C1C=CC=C3C(=O)N(CCNCC1=NN=C(C)S1)C2=O

J Am Anim Hosp Assoc

Ro-3306 te N-desmethyl Netupitant 460(7258):1031-4RO 3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO 3306 induced G2 M phase cell cycle arrest and apoptosis in a dose and time dependent manner. RO 3306 downregulated expression of the antiapoptotic proteins Bcl 2 and survivin and blocked p53 mediated induction of p21 and MDM2. RO 3306 actively enhances downstream p53 signaling to promote apoptosis. Product information CAS Number: 872573 93 8