The best is to stop them being created in the first place
Item cards can be played as many times as desired during your turn, before attacking, and offer effects like drawing cards, searching your deck for specific Pokmon, or healing damage
How many are worth considering if youre not all-in on playing a Spider Hero or Villain deck
Sealed booster boxes carry a premium, not just for the cards they contain but for the potential they hold
Like Doom Blade, Smother is not an effect you want to overload on for those matchups where it is dead or low returns
This started first with the brands Dandan deck and was followed by the announcement of Mark Rosewaters Mood Swings, a deck-based game that is adjacent to but not the same as Magic