A 438079 417 and inhibits the increases in

and inhibits the increases in swiprosin-1 in HRGECs incubated with HG

Formula: C23H33N5O2

Smiles: CC(C)(C)NC(=O)NC1=NC2=NC(N)=NC=C2C=C1C1C=C(C=C(C=1)OC)OC

CAS Number: 27741-01-1

InChi: InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H

A 438079 417 and inhibits the increases inA 438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A 438079 partially but significantly prevented the 6 OHDA induced depletion of striatal DA stores. P2X7R inhibitor A 438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure induced neuronal death in the neocortex. Blockade of P2X(7) receptors