GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 la-Ala-Asn-PAB-PNP BAY 87-2243 was used at

BAY 87-2243 was used at 0

Discovery of I-BRD9

TAK-875 was used at 1 µM final concentration in various in vitro assays

Smiles: CC1=NOC2[C@H](CC(N)=O)N=C(C3=CC=CC=C3C=21)C1C=CC(Cl)=CC=1

Formula: C22H23ClFN5O3

GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 la-Ala-Asn-PAB-PNP BAY 87-2243 was used atGNF7156, CAS No. 2041071 54 7, is a highly potent and selective small molecule that promotes pancreatic cell proliferation in rodent EC50 ~2. 2 Mand human primary islets (EC50 ~0. 76 M). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156 treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces cell proliferation, increases cell mass