Beta-Eudesmol n Dihydrochalcone selective and orally bioavailable DYRK1A

selective and orally bioavailable DYRK1A inhibitor with IC50 of 80 nM

Epub 2020 Jul 13

InChiKey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N

osteoclast activity is inhibited and bone resorption and turnover are reduced

Harmine was dosed by intraperitoneal injection at 10 mg/kg in mouse partial pancreatectomy model (PPX)

Beta-Eudesmol n Dihydrochalcone selective and orally bioavailable DYRK1ABeta Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32. 5 M. Beta Eudesmol increases appetite through TRPA1. Product information CAS Number: 473 15 4 Molecular Weight: 222. 37 Formula: C15H26O Chemical Name: 2 [(2R,4aR,8aS) 8a hydrogenio 4a methyl 8 methylidene decahydronaphthalen 2 yl]propan 2 ol Smiles: CC(C)(O)[C@H]1C[C@H]2C(=C)CCC[C@]2(C)CC1 InChiKey: BOPIMTNSYWYZOC VNHYZAJKSA N InChi: InChI=1S C15H26O c1 11 6 5