Exatecan Mesylate - CAS# 169869-90-3 0271 Smiles: [O-][N+](=O)C1=CC(Cl)=CC=C1S(=O)(=O)C1C=CC=CC=1

Smiles: [O-][N+](=O)C1=CC(Cl)=CC=C1S(=O)(=O)C1C=CC=CC=1

which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

PubMed Central PMCID: PMC4292866

and suppressed tumor growth in vivo with a concomitant reduction in vessel formation

FPS-ZM1 inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain

Exatecan Mesylate - CAS# 169869-90-3 0271 Smiles: [O-][N+](=O)C1=CC(Cl)=CC=C1S(=O)(=O)C1C=CC=CC=1Exatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater