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PubMed Central PMCID: PMC4697154
but not in the WT cells at any concentrations
It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0
Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells
PubMed PMID: 27562646
WHI-P258 - CAS# 21561-09-1 60187 PubMed Central PMCID: PMC4697154WHI P258, CAS No. 21561 09 1, is a Janus kinase 3 inhibitor. WHI P131 may provide the basis for the design of new treatment strategies against acute lymphoblastic leukemia, the most common form of childhood cancer. Product information CAS Number: 21561 09 1 Molecular Weight: 281. 31 Formula: C16H15N3O2 Synonym: WHI P258 WHI P 258 WHIP 258 WHI P 258 Chemical Name: 6,7 Dimethoxy N phenylquinazolin 4 amine Smiles: COC1=CC2=NC=NC(NC3C=CC=CC=3)=C2C=C1OC
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