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BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve
PubMed Central PMCID: PMC3969090
70 and 200 nM for IKKβ
27 mg/mL(42
plasma membrane electron transport system
Brevetoxin-3 - CAS# 85079-48-7 333Acetyl lysyltyrosylcysteine amide BQ 788 (3 mg/kg) resultsBrevetoxin 3 (PbTx 3) is a potent allosteric voltage gated Na+ channel activator and has multiple active centers (A ring lactone, C 42 of R side chain). Brevetoxin 3 (PbTx 3) has a high affinity to site 5 of the voltage sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin 3 (PbTx 3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.
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